What is an example of a systemic effect from pesticide exposure?

A systemic effect from pesticide exposure refers to a response that affects the entire body or multiple organ systems, rather than being localized to one area. Blood clotting impairment is a significant example of a systemic effect because it indicates the pesticide has penetrated the body, entering the bloodstream and affecting the physiological processes that regulate blood coagulation. This type of response can have widespread implications for health, potentially leading to more severe complications.

In contrast, responses such as skin irritation, nausea, and mild headache are typically localized or acute effects that do not indicate systemic involvement. Skin irritation is often a direct reaction at the site of contact, nausea can result from gastrointestinal irritation or distress, and a mild headache, while uncomfortable, may not necessarily involve systemic effects or widespread physiological changes. Thus, blood clotting impairment is the most representative example of a systemic effect from pesticide exposure, emphasizing the need for careful handling and application of these substances.