Which organ systems can be affected by systemic toxicity?

Systemic toxicity can impact multiple organ systems in the body, and the liver and kidneys are particularly significant in this context. The liver plays a crucial role in metabolizing chemicals and toxins, often converting them into less harmful substances that can then be excreted. When a substance causes systemic toxicity, it can overwhelm the liver's ability to process and detoxify, leading to damage or dysfunction.

Simultaneously, the kidneys are essential for filtering waste products and excess substances from the bloodstream. When systemic toxicity occurs, the kidneys can also be affected, as they may struggle to accommodate the increased burden of toxins that need to be eliminated from the body.

The other options focus on single organs, which do not reflect the broader scope of systemic toxicity. Skin and lungs may experience localized effects when exposed to toxins, but they are not the primary organs involved in systemic toxicity where profound effects are often more visible and significant in the liver and kidneys. Therefore, the correct choice highlights the interconnectedness of different organ systems when it comes to the effects of systemic toxicity.